Endocrine Abstracts

Background: Recent studies have suggested an important role of advanced glycosylation end products receptor (RAGE) in the development of atherosclerosis. However, investigation of the relationship between RAGE polymorphisms (−429T/C, −374T/A) and coronary heart disease (CHD) has shown contradictory results. Furthermore, hyperandrogenemia in women postmenopause has been associated with an adverse CHD risk profile.Aim of the study: To investiga...

Background: Polycystic ovary syndrome (PCOS) is a complex metabolic disorder and hyperandrogenism and insulin resistance constitute the key players of syndrome pathogenesis. Another emerging important factor of PCOS is low-grade chronic inflammation. The aim of the present study was to investigate white blood cells count (WBC) in PCOS and assess its role as a possible marker of low-grade inflammation.Methods: Anthropometrical, metabolic and hormonal data...

Objective: To investigate the effects of oral natural micronized progesterone on hormonal and metabolic parameters in patients with polycystic ovary syndrome (PCOS) and to answer the clinical question if induction of withdrawal bleeding is a necessity for the comparison of hormonal and metabolic data in PCOS subjects.Design: Prospective clinical study.Setting: Academic medical centre.Population: Twenty eight ...